Principal Investigator: Jacqueline Hebert Co-Investigators: Hollie Power, Adil Ladak, Robert Stiegelmar, Patrick Pilarski and Ahmed Shehata This study aims to optimize prosthetic outcomes after transhumeral (above elbow) osseointegration (OI) and targeted muscle reinnervation (TMR). Participants will undergo the OI and TMR surgeries, followed by intensive training using virtual training tools and fitting with an advanced myoelectric prosthesis. We will assess whether this new system will improve prosthesis use in daily life and lead to greater satisfaction with the prosthesis. We are actively recruiting participants for this pilot clinical trial.  If you have an arm amputation above the elbow (transhumeral), are between 18–65 years old, and are interested in hearing more about the study, please fill out the form below to be contacted by the research team for screening. This research project is funded by The Congressionally Directed Medical Research Program, United States Department of Defense; FY22 Peer Reviewed Orthopaedic Research Program; Award No. W81XWH-22-PRORP-CTRA

Principal Investigators: Adil Ladak, Hollie Power Co-Investigators: Jacqueline Hebert, Robert Stiegelmar This project investigates whether advanced nerve-reconstruction techniques—Targeted Muscle Reinnervation(TMR) and Regenerative Peripheral Nerve Interface (RPNI)—provide superior long-term relief for post-amputation pain compared to the current standard of care, neuroma transposition. While neuroma transposition involves simply burying a severed nerve into nearby muscle or bone, TMR and RPNI provide the nerve with a "functional" target (a motor endplate or a small muscle graft), theoretically preventing the disorganized axonal growth that leads to painful neuromas. The primary objective is to determine if these approaches result in clinically significant improvements in Phantom Limb Pain (PLP) and Residual Limb Pain (RLP) at a 2-year follow-up, offering a definitive comparison of durability and efficacy between "bio-integrative" and "re-positional" surgical strategies. We are actively recruiting participants for this clinical trial. If you are >18 years old, have a major limb amputation at any level (upper or lower limb), experience nerve pain in your residual limb or phantom limb pain, and are interested in being assessed for the study, please fill out the form below to be contacted by the research team for screening. Funding support is provided from the University of Alberta Hospital, University Hospital Foundation, and the University of Alberta, through the Kaye Grant Competition